The esteemed position of the Quran among Muslims has profoundly influenced their intellectual and scientific systems; consequently, any understanding of the intellectual and scientific framework of Muslims is contingent upon and dependent on an understanding of the Quran. Conversely, numerous narratives exist concerning the Quran and its destiny, and its content is remarkably diverse. As a result, uncovering and analyzing the Quran’s position within the cognitive and scientific system of Muslims presents a unique complexity. This article, through inductive analysis of Quranic verses, a literature review of Islamic scholarly works, and an examination of the statements of both Islamic and non-Islamic scholars regarding the Quran, seeks to present a clear picture of the Quran’s position across various dimensions. The research findings indicate that, from an Islamic perspective, the Quran is a divine, immutable, and unparalleled heavenly book. This book is revered by all Muslims at all levels and is considered the origin and source of all Islamic sciences. The Quran is comparable to other divine scriptures, yet superior to them, and is respected by many non-Muslims. While some non-Muslim scholars have presented critiques of the Quran, Islamic thinkers do not consider these critiques to be valid. In conclusion, the Quran occupies a central position within the cognitive and knowledge system of Muslims, and this system loses its true essence without the Quran.